A game-changer for chronic


Achieve total and faster wound healing with AUP-16, a topical cell therapy that accelerates healing of diabetic foot ulcers and other chronic, non-healing wounds.

Chronic and non-healing wound treatment is


Many available products can treat symptoms or target limited steps in the wound healing pathway: traditional or moist wound dressings, negative pressure wound therapy, cell and tissue based products, skin substitutes, growth factors.... Aurealis Therapeutics’ four-in-one topical treatment, AUP-16, accelerates healing by targeting multiple wound healing pathways and promoting tissue regeneration. Our unique technology overcomes the limitations of combining current treatments or combining existing therapeutic protein treatments, replacing them with a single therapeutic agent.


One medicine has the benefits of four therapeutics

AUP-16 is a safe and effective recombinant live biotherapeutic product that features a patented active bacterial vector containing three therapeutic proteins (FGF2, IL4, and CSF1), produced continuously at the site of the wound, providing a combination biologic treatment in one product.

AUP for treatment of diabetic foot ulcer

This novel therapeutic is backed by pre-clinical and clinical results in wide-ranging applications like diabetic foot ulcers, other non-healing wounds, and inflammatory diseases. AUP-16 is made from live, food-grade bacteria and has the power to accelerate and provide complete wound healing, making future amputations unnecessary.

This remarkable advancement is ideal for patients who only achieve partial response to wound care dressings and treatment of symptoms. As opposed to the existing standard of care, AUP-16 promotes tissue regeneration in the wound to activate healing from within.

Highlights of AUP-16


cell therapy stimulates
tissue regeneration


protein production
at the site of injury

Topical Application

makes it easy to


modified food-
grade bacteria

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Aurealis Therapeutics and Xbiome Enter into a License and Collaboration Agreement for Aurealis Four-in-One Diabetic Foot Ulcer and Inflammatory Disease Cell and Gene Therapy AUP-16 in Greater China

Basel Switzerland, Kuopio Finland, and Shenzhen China – January 28th, 2021. Aurealis Therapeutics, a synthetic biology company developing groundbreaking four-in-one cell and gene therapies and Xbiome, an AI-based microbiome drug development company, today announced that the two companies have entered into an exclusive license and collaboration agreement for the clinical development and commercialization of Aurealis … Aurealis Therapeutics and Xbiome...


Aurealis Therapeutics Diabetic Foot Ulcer Dose Escalation Patient Trial Low Therapeutic Dose Cohort Completed Successfully, Advances to Medium Therapeutic Dose Group

Basel Switzerland, Kuopio Finland – May 27th, 2021.  Aurealis Therapeutics, a biopharmaceutical company developing its groundbreaking four-in-one technology -based product AUP-16, announced today that it has successfully completed the low therapeutic dose cohort in the diabetic foot ulcer (DFU) patient trial and has already enrolled and dosed the first patients in the medium therapeutic dose … Aurealis Therapeutics Diabetic Foot...


Aurealis Therapeutics Novel Chronic Wound Treatment to be Presented at the 4th Experts Meeting on Microbiome & Skin Health and Disease on December 15th, 2020

Basel Switzerland, Kuopio Finland – December 15th, 2020. Haritha Samaranayake, MD, PhD, Medical Director of Aurealis Therapeutics will give a talk about development of AUP16, the company´s lead product for non-healing wounds such as diabetic foot ulcer. The presentation is titled “Development of a Live Biotherapeutic to treat diabetic foot ulcer“ and is scheduled for … Aurealis Therapeutics Novel Chronic...